FIELD: medicine.
SUBSTANCE: invention proposes using recombinant protein with the molecular mass 12 kDa from leech, Hirudo medicinalis, (saratin) that inhibits vWF-dependent formation of bond of platelets with artery wall collagen under condition of enhanced shift. Proposed agent is used for inhibiting platelets accumulation after vessel damage or endarterectomy for prevention of adhesion of platelets, thrombosis and restenosis. Also, invention proposes a coat for surface of surgery device or surgery tool based on thereof, hydrogel coat of catheter for administration and local delivery of saratin and using saratin as an agent for coat of surgery device or surgery tool, i. e. catheter, stent or intravascular transplant. Invention displays decreasing rate in thrombosis development and vessels occlusion in point of impact being in the absence of systemic effects as saratin doesn't influence on systemic bleeding and amount of platelets.
EFFECT: valuable medicinal properties of agent.
10 cl, 3 tbl, 9 dwg, 12 ex
