FIELD: medicine.
SUBSTANCE: claimed invention relates to biotechnology and represents a polypeptide construction for treatment, prevention and relief of disorders, associated with an adhesion of platelets and platelet-mediated aggregation or its dysfunction, which includes one or more single-domain antibodies, aimed against the von Willebrand factor (vWF), and one or more single-domain antibodies aimed against serum albumen (SA). The invention also relates to nucleic acid, coding such polypeptide construction, to compositions, containing the said construction, and to its application for obtaining medications for prevention, treatment and relief of the said disorders.
EFFECT: claimed invention makes it possible to extend an assortment of medications for treatment, prevention and relief of disorders, associated with the platelet adhesion and platelet-associated aggregation or its dysfunction.
15 cl, 30 dwg, 32 tbl, 69 ex
| Title |
Year |
Author |
Number |
| THERAPEUTICAL POLYPEPTIDES, THEIR HOMOLOGS, FRAGMENTS, AND APPLICATION IN THROMBOCYTE-MEDIATED AGGREGATION MODULATION |
2004 |
|
RU2357974C2 |
| SINGLE-DOMAIN ANTIBODIES DIRECTED AGAINST TUMOUR NECROSIS FACTOR ALPHA, AND USE THEREOF |
2012 |
- Silans Karen
- Loverejs Mark
- De Khard Khans
|
RU2704232C2 |
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2004 |
- Sho Grej
- Sako Dajann S.
- Kumar Ravindra
- Sjuj Tszin'
|
RU2403262C2 |
| INHIBITORS FOR USING IN HEMOSTASIS AND IMMUNE FUNCTION |
2000 |
- Sheppard Pol O.
- Lehsser Dzherald U.
- Bishop Pol D.
|
RU2239449C2 |
| METHODS OF TREATING TTP WITH IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS AND USES THEREOF |
2015 |
|
RU2704444C2 |
| PEPTIDE OR PEPTIDE COMPLEX BINDING TO alpha2- INTEGRIN, METHODS FOR PRODUCTION AND USE THEREOF |
2011 |
- Korvej Karsten
- Blum Khorst
- Kameron Beatris
- Dabdubi Tarik
- Dekari Stefani
- Boren Nikolya
- Papen David
- Lange Kristian
|
RU2588668C2 |
| PROTEIN BOUND WITH HUMAN GLYCOPROTEIN, COMPOSITION, PHARMACEUTICAL COMPOSITION, EXPRESSION VECTOR |
2016 |
- Bilalde Filip
- Zhanro-Perrus Martine
|
RU2773819C2 |
| IMPROVED AMINO ACID SEQUENCES AGAINST IL-6R AND POLYPEPTIDES WHICH CONTAIN THEREOF FOR TREATMENT OF IL-6R ASSOCIATED DISEASES AND DISORDERS |
2010 |
- Bajrnaehrt, Ehl'S, Anna, Ehllis
- Ververken, Sedrik, Jozef, Neotere
- Kolkman, Jost, Aleksander
- Van Roj, Marten
|
RU2539798C2 |
| COMPOSITION, INHIBITING PLATELET AGGREGATION |
2006 |
- Josida, Sigeto
- Sudo, Tosiki
|
RU2557296C2 |
| POLYPEPTIDE, POSSESSING INHIBITING ACTIVITY WITH RESPECT TO PLATELET AGGREGATION AND/OR INHIBITING ACTIVITY WITH RESPECT TO PLATELET ADHESION, ENCODING IT POLYNUCLEOTIDE, COMPOSITION AND SET, CONTAINING SAID POLYPEPTIDE |
2006 |
|
RU2434941C2 |
