PEPTIDE-BASED COMPOUNDS FOR DIRECTED TRANSPORT TO INTEGRIN RECEPTORS Russian patent published in 2007 - IPC C07K7/06 C07K14/745 A61K49/00 A61K51/08 

FIELD: pharmaceutical chemistry.

SUBSTANCE: invention provides novel compounds of general formula (I) and pharmaceutically acceptable salts thereof, wherein G represents glycin; D aspartic acid; R₁ group -(CH₂)n- or -(CH₂)n-C₆H₄-; n is integer from 1 to 10; h is 1 or 2; X₁ represents amino acid residue having one functional deviation such as amine; X₂ and X₄ independently represent amino acid residue capable of forming disulfide bond; X₃ represents hydrophobic amino acid such as phenylalanine; X₆ represents group -NH-[CH-]-C(O)-; X₇ is missing or represents biomodifying grouping consisting of monodisperse poly(ethylene glycol): (II), wherein is integer from 1 to 10; C-end unit represents amide group or 1-10 amino acid residues; Z₁ chelating group or reporter group; and W₁ is missing or represents spacing moiety derived from glutaric or succinic acid. Compounds of invention are designed as diagnostic agents for visualization or as therapeutic agents, the two agent types being directional vectors capable of binding to integrin receptors.

EFFECT: expanded diagnostic and therapeutic possibilities.

19 cl, 3 tbl, 5 ex