GLP-1 PEPTIDE HAVING ATTACHED OLIGOSACCHARIDE CHAIN Russian patent published in 2015 - IPC C07K14/605 A61K38/26 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to biotechnology, specifically to a GLP-1 peptide having an attached oligosaccharide chain, and can be used in medicine. Said GLP-1 peptide, having GLP-1 activity, has (a1) one amino acid further attached to the C end (position 37), wherein said attached amino acid is replaced with an amino acid with an attached oligosaccharide chain; or (a2) one or two amino acids, replaced with an amino acid with an attached oligosaccharide chain, where the replacement site is selected from positions 18, 20, 22, 30 and 36, and can further include 1 to 5 amino acid deletions, replacements or inserts, where said oligosaccharide chain contains five or more sugars and is represented by Formula 1. The invention also relates to a pharmaceutical composition and a method of treating or preventing diseases which can be treated or prevented by administering GLP-1, for example diabetes, which comprises use of said GLP-1 peptide having an attached oligosaccharide chain.

EFFECT: invention enables to obtain a GLP-1 peptide having an attached oligosaccharide chain, having improved stability and higher activity in controlling blood sugar level compared to GLP-1.

14 cl, 22 dwg, 10 tbl, 49 ex