FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns biochemistry and medicine area. What is presented is a visualisation agent representing a conjugate of structure I as described in the patent claim. The visualisation agent refers to marked cMet-binding peptides. These peptides include a mark with an optical reporter group applicable for visualisation in vivo with the use of light within the range of wave length in the spectrum of 600-1200 nm. There are also presented a pharmaceutical composition for optical visualisation, containing the visualisation agent, a kit for preparing it and a method for optical visualization of a mammalian body in vivo. What is also presented is a method for managing the patients suffering colorectal cancer, involving the stage of optical visualisation in vivo.
EFFECT: presented visualisation agent possess higher cMet-binding affinity and selective cell targeting in vivo.
28 cl, 2 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION FOR OPTICAL VISUALIZATION, METHOD OF ITS PRODUCTION AND USE | 2019 |
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| MONOCLONAL BINDING AGENTS, THEIR DRUG CONJUGATES AND THEIR APPLICATIONS | 2017 |
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