IMIDAZOLYDINE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL AGENT BASED ON THE SAME Russian patent published in 2007 - IPC C07D233/74 C07D233/76 C07D401/12 A61K31/4166 A61K31/4178 A61P29/00 A61P9/00 

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to new imidazolydine derivatives of formula I wherein A is cyclopropylmethyl or isobuthyl; E is -CO-R⁶ or -CH₂-O-R⁷; Z is oxygen; R¹ is hydrogen or methyl; R² is phenyl, pyridyl or C₁-C₄-alkyl; R³ and R⁴ are methyl or trifluorometyl; R⁵ is hydrogen or C₁-C₄-alkyl; R⁶ is hydroxyl; R⁷ is hydrogen; or R- or S-stereomeres, or R/S-stereomere mixture, or physiologically acceptable salts thereof. Said derivatives represent valuable pharmaceutically active compounds, useful in treatment of e.g. rheumatoid arthritis or allergic diseases. Derivatives of formula I are inhibitors of leukocyte adhesion and migration and/or antagonists of VLA-4 adhesion receptor from integrine group. Said derivatives are useful in treatment of diseases associated with undesired leukocyte adhesion and/or migration, as well as diseases mediated by intracellular interaction or cell-matrix interaction. Method for production of compound of formula I and pharmaceutical agent based on the same also are disclosed.

EFFECT: new imidazolydine derivatives useful as pharmaceutical agents.

14 cl, 23 ex