METHOD AND INTERMEDIATES FOR HEPTAPEPTIDE PRODUCTION Russian patent published in 2007 - IPC C07K1/06 C07K7/06 

FIELD: pharmaceutical chemistry.

SUBSTANCE: invention relates to method for production of heptapeptide of general formula: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH having psychostimulating activity. Synthesis is carried out by condensation of C-terminal protected tripeptide of formula HCl.H-Pro-GlY-Pro-OX, wherein X is protective group, with protected N-terminal tetrapeptide of formula Y-Thr-Lys(Y¹)-Pro-Arg-OH, wherein Y and Y¹ are protective groups, and obtained protected heptapeptide of formula Y-Thr-Lys(Y¹)-Pro-Arg-Pro-Gly-Pro-OX is treated with deprotecting reagents to remove protective groups and target product is isolated by chromatography method. Also described are tripeptide of formula HCl.H-Pro-GlY-Pro-OBzl and tetrapeptide of formula Boc-Thr-Lys-(Boc)-Pro-Arg-OH as intermediates for synthesis of heptapeptide of general formula: H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH.

EFFECT: simplified process; increased yield of target product.

4 cl, 7 ex