FIELD: pharmaceutical chemistry.
SUBSTANCE: invention relates to method for production of tripeptides of general formula I: A-Pro-GlY-Pro-OX, wherein A is H, Bzl, t-Bu. Synthesis is carried out by liquid phase method by condensation of C-terminal proline derivatives of general formula H-Pro-OX1, wherein X1 is Bzl, t-Bu with protected dipeptide of general formula Y-Pro-Gly-OH, wherein Y is Z, Boc, and obtained protected tripeptide of general formula Y-Pro-Gly-Pro-X1 is treated with deprotecting reagents and optionally obtained product is acetylated and optionally hydrochlorides are obtained.
EFFECT: improved method for tripeptide production.
2 cl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD AND INTERMEDIATES FOR HEPTAPEPTIDE PRODUCTION | 2006 |
|
RU2303603C2 |
| METHOD FOR PREPARING ADRENOCORTICOTROPIC HORMONE (ACTH) ANALOGS, SEQUENCE (4-10), POSSESSING NEUROTROPIC ACTIVITY AND TETRAPEPTIDE FOR ITS PREPARING | 2006 |
|
RU2315057C2 |
| METHOD OF OBTAINING DODECAPEPTIDE AND TRIPEPTIDE FOR ITS REALISATION | 2007 |
|
RU2340626C1 |
| SORBENT FOR REMOVAL OF IMMUNOGLOBULINS | 2008 |
|
RU2389022C2 |
| OCTAPEPTIDE AMIDE, CAPABLE OF RAISING BLOOD PRESSURE AND CARDIAC RATE | 2007 |
|
RU2346001C1 |
| PEPTIDES POSSESSING CYTOPROTECTIVE ACTIVITY | 2011 |
|
RU2482128C1 |
| METHOD FOR PRODUCING TRIPEPTIDE DIACETATE | 2014 |
|
RU2551276C1 |
| METHOD FOR OBTAINING TREPEPTIDE OF GENERAL FORMULA (I) HPyr-His-TrpOH, APPLIED AS INTERMEDIATE COMPOUND (1-3 FRAGMENT) IN SYNTHESIS OF SYNTHETIC AGONISTS OF GONADOTROPIN-RELEASING-HORMONE (LH-RH), BY METHOD OF LIQUID-PHASE PEPTIDE SYNTHESIS WITHOUT PLACING AND REMOVAL OF PROTECTIVE GROUPS | 2014 |
|
RU2574392C1 |
| WAY OF BUSERELIN PRODUCTION AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION | 2010 |
|
RU2442791C1 |
| PEPTIDE DERIVATIVES AND METHOD OF THEIR PRODUCTION | 1992 |
|
RU2087480C1 |
