FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to a solid medicinal composition providing pH-independent release of active substance and comprising (2R)-1-{[4-chloro-2-(ureido)phenoxy]methyl}carbonyl-2-methyl-4-(4-fluorobenzyl)piperazine or one of its salts, polymeric matrix, pharmaceutically acceptable organic acid, lubricating additive and one or some accessory substances and wherein size of 90% of particles in powdery mixtures is from 0.1 to 750 mcm. Except for, invention relates to methods for preparing and using this medicinal composition.
EFFECT: valuable pharmaceutical properties of composition, improved preparing method.
22 cl, 11 dwg, 22 ex
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