FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for synthesis of 2-imidazolylpropane-2-sulfoacid. Invention describes a method for synthesis of 2-imidazolylpropane-2-sulfoacid that involves dissolving imidazole in a solvent, such as lower alcohols or acetone, bubbling gaseous sulfurous anhydride in its at temperature 200C, not above, for 20-25 min in the mass ratio imidazole : sulfurous anhydride = 1:1 and addition of propanone-2 in the mass ratio imidazole : propanone-2 : water = 1:1:1. Method provides preparing the end product of high purity (99.2-99.8%) with the high yield (89-92%) and to exclude using a solvent prohibited by Pharmacological committee of Russian Federation. Synthesized compound possesses bacteriostatic, immunostimulating, anti-aggregating and de-aggregating activity with respect to platelets and enhancing contracting activity of skeletal muscles.
EFFECT: improved method of synthesis, valuable medicinal properties of compound.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 2-IMIDOZOLYLPROPAN-2-SULPHACID APPLICATION AS BACTERISTIC, IMMUNOSTIMULATING, ANTIAGGREGATORY, THROMBOCYTES DEAGGREGATING AGENT STIMULATING CONTRACTIVE ACTIVITY OF SKELETAL MUSCLES | 2006 |
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| PROCESS FOR PREPARING 1,2,3,4-TETRAHYDRO-2-METHYL-1,4- DIOXONAPHTHALENE-2-SULFOACID SODIUM SALT (VICASOL) | 1997 |
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