FIELD: pharmacology.
SUBSTANCE: group of inventions is N,N-bis(2-(dialkylamino)ethyl)carboxamides and their dihydrochlorides of the general formula: 
, where when R=C6H5OCH2, and R1=CH3, then NR22=N(CH3)2 or NC5H10; when R=C6H5OCH2, and R1=C2H5, then NR22=N(C2H5)2, NC4H8, NC5H10 or NC4H8O; when R=2.4-Cl2C6H3OCH2, and R1=CH3, then NR22=N(CH3)2, NC4H8 or NC5H10; when R=2.4-Cl2C6H3OCH2, and R1=C2H5, then NR22=N(C2H5)2, NC4H8, NC5H10 or NC4H8O, with NC4H8 is pyrrolidino, NC5H10 is piperidino, NC4H8O is morpholino. The group of inventions includes a drug and a pharmaceutical composition, which contain compounds described previously as an active agent and have anti-arrhythmic activity.
EFFECT: expanded arsenal of drugs with low toxicity and high antiarrhythmic activity, promising for development of medicines on their basis for treatment of cardiac arrhythmias.
3 cl, 3 dwg, 4 tbl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-(2-(2-(DIALKYLAMINO)ETHOXY)ETHYL)CARBOXAMIDES AND HYDROCHLORIDES THEREOF, HAVING ANTIARRHYTHMIC ACTIVITY, AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2019 |
|
RU2712638C1 |
| 2-(2-(DIALKYLAMINO POLYETHOXY))ETHYL CARBOXYLATES AND HYDROCHLORIDES THEREOF WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2020 |
|
RU2775616C2 |
| QUATERNARY AMMONIUM SALTS BASED ON DERIVATIVES OF VITAMIN B6 | 2015 |
|
RU2607522C1 |
| 4-SUBSTITUTED N-ARYL-1,8-NAPHTHALIMIDES, EXHIBITING PROPERTIES OF FLUORESCENT SENSORS ON METAL CATIONS AND METHODS FOR PRODUCTION THEREOF | 2012 |
|
RU2515195C1 |
| ANTIBACTERIAL AGENTS BASED ON QUATERNARY AMMONIUM SALTS | 2014 |
|
RU2561281C1 |
| SUBSTITUTED ISOXAZOLES, PHARMACEUTICAL COMPOSITIONS BASED THEREON HAVING ANTIVIRAL ACTIVITY, AND METHOD FOR USE THEREOF | 2018 |
|
RU2733945C2 |
| ANTIBACTERIAL AGENTS ON BASIS OF CIPROFLOXACIN DERIVATIVES | 2016 |
|
RU2636751C1 |
| METHOD OF PRODUCING 5,8-(BIS(METHYLENE(N,N-DIMETHYL-N-DODECYLAMMONIUM))-2-ETHYL-4H-[1,3]DIOXINO[4,5-C]PYRIDINIUM DICHLORIDE | 2019 |
|
RU2697848C1 |
| QUATERNARY AMMONIUM COMPOUNDS BASED ON PENTAERYTHRITOL AND PYRIDOXINE DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | 2023 |
|
RU2811203C1 |
| N,N'-DI(ALKADINYL)DIAZACYCLOALKANES AND METHOD OF PRODUCING N,N'-DI(ALKADINYL)DIAZACYCLOALKANES EXHIBITING FUNGICIDAL ACTIVITY WITH RESPECT TO FUNGI BIPOLARIS SOROKINIANA AND RHIZOCTONIA SOLANI | 2019 |
|
RU2727138C1 |
