FIELD: medicine, hematology, organic chemistry, pharmacy.
SUBSTANCE: invention relates to novel peptidylarginals of the formula (I): Xaa-Xbb-Arg-H wherein Xaa means residue of alpha-substituted carbonic acid of the formula (II): Q-CH(R)-CO wherein Q means (C1-C3)-alkyloxycarbonylamino-group, methylamino-group or hydroxyl group; R means (C7-C9)-cycloalkylmethyl group or (C5-C7)-cycloalkyl group; Xbb means residue of L-proline or L- azethidine-2-carboxylic acid, and its additive acid salts formed by organic or inorganic acid. Intermediate compounds are described also. Compounds of the formula (I) possess the inhibitory effect on free thrombin, thrombin bound with a clot, Xa factor, plasmin and plasminogen activators that allows their using in pharmaceutical composition in treatment of a patient suffering from disseminated intravascular coagulation syndrome.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
17 cl, 4 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING D-PHENYLALANYL-D-PROLYL-L-ARGININE-ALDEHYDE SULFATE | 0 |
|
SU1442078A3 |
| METHOD OF PRODUCING PEPTIDYL-ARGININE-ALDEHYDE SULFATES | 0 |
|
SU1384203A3 |
| DERIVATIVES OF BENZAZEPINE AND BENZOTHIAZEPINE | 1989 |
|
RU2090562C1 |
| METHOD OF SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2026296C1 |
| METHOD OF PRODUCING ARYLAMIDES OF AMINO ACIDS OR PEPTIDES, OR THEIR SALTS | 0 |
|
SU1512484A3 |
| PROCESS FOR PREPARING POLYPEPTIDES OR THEIR SALTS | 0 |
|
SU910116A3 |
| TRIPEPTIDE DERIVATIVES AS R- OR RS-FORMS OR THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2077538C1 |
| 6-(TOSYLGLYCYL-L-PROLYL-L-ARGINYL)-AMINONAPHTHALENE-1- ISOBUTYL-SULFAMIDE AS SUBSTRATE FOR THROMBIN ASSAY BY FLUORESCENT METHOD | 1991 |
|
RU2087481C1 |
| METHOD OF PRODUCING OCTAPEPTIDE | 0 |
|
SU1147010A1 |
| PROCESS FOR PRODUCING THIPEPTIDE AMIDES | 0 |
|
SU963463A3 |
