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2 087 481

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IPC

(21) (22)

Application

4932256/04, 1991-03-19

(22)

Actual filing date

1991-03-19

(45)

Published

1997-08-20

(72)

Inventor

Butenas Sauljus Juozovich[Lt]Palajma Al'Girdas Ionovich[Lt]Baltenas Visval'Das Rajmundovich[Lt]Poshkene Regina Aleksovna[Lt]

(73)

Holder

Institut Biokhimii Litovskoj An

6-(TOSYLGLYCYL-L-PROLYL-L-ARGINYL)-AMINONAPHTHALENE-1- ISOBUTYL-SULFAMIDE AS SUBSTRATE FOR THROMBIN ASSAY BY FLUORESCENT METHOD Russian patent published in 1997 - IPC

Abstract RU 2087481 C1

FIELD: organic chemistry. SUBSTANCE: product: 6- (tosyl-glycyl-L-prolyl-L-arginyl)-aminonaphthalene-1- isobutylsulfamide. Reagent 1: Tos-Gly-L-Pro-OH. Reagent 2: 6-L-arginylaminonaphthalene-1-isobutylsulfamide bromohydrate. Process is carried out in anhydrous dimethylformamide (DMFA) in the presence of 1-hydroxybenzotriazole and dicyclohexylcarbodiimide. Yield is 75%, [α]20D

= 38.0 (c=1, in dimethylsulfoxide; DMSO), m. p. is 156-160 C. Effectiveness of the proposed substrate is 3-fold as compared with the known one (Chromozym; TH) for 10% hydrolysis by time. EFFECT: improved method of synthesis, increased effectiveness of substrate. 2 tbl, 1 dwg

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RU 2 087 481 C1

Authors

Butenas Sauljus Juozovich[Lt]

Palajma Al'Girdas Ionovich[Lt]

Baltenas Visval'Das Rajmundovich[Lt]

Poshkene Regina Aleksovna[Lt]

Dates

1997-08-20—Published

1991-03-19—Filed