SOLID MEDICINAL FORMULATION OF HEPATOPROTECTIVE EFFECT Russian patent published in 2008 - IPC A61K9/48 A61K9/20 A61K31/685 A61K31/35 A61P1/16 

FIELD: chemical-pharmaceutical industry, medicine, pharmacy.

SUBSTANCE: invention relates to a solid medicinal formulation of hepatoprotective effect that comprises combination of flavanolignan with phopholipids as active components and special additive - colloidal silicon dioxide, polyvinylpyrrolidone, trehalose, sodium stearylfumarate, calcium phosphate and/or mannitol. Method for preparing this medicinal formulation involves a wetting step of mixture of phospholipid with colloidal silicon dioxide with small amount of water in the mass ratio about 2:1, respectively, addition of flavanolignan, calcium phosphate and/or mannitol, trehalose followed by wetting the mixture with 15% polyvinylpyrrolidone aqueous solution, wet and dry granulation and powdering dry granulate with sodium stearylfumarate. Agent is prepared in form of capsule preferably. Invention provides simplifying technology and enhancing stability of agent and expands assortment of agents of hepatoprotective effect.

EFFECT: improved and valuable medicinal properties of formulation.

4 cl, 1 tbl