METHOD OF OBTAINING MEDICAL FORM OF TRIMETAZIDINE OF PROLONGED ACTION Russian patent published in 2014 - IPC A61K31/495 A61K47/32 A61K47/38 A61K9/16 A61K9/32 A61J3/10 A61P9/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to a method of preparing a drug form of trimetazidine dihydrochloride with the modified release. According to the method modifiers of release - Kollidon SR and hydroxypropylmethylcellulose are mixed, trimetazidine dihydrochloride is added to the mixture, microcrystalline cellulose is mixed with an aerosol in a separate vessel and sifted to obtain a homogenous mass, two mixtures are mixed with each other, powdered with sliding substances, the obtained mass is pressed with the following application of a film coating Opadry II on tablet cores, with taking 10-40% of trimetazidine dihydrochloride, 10-70% of the said modifier of release, 10-80% of the said filler, 0.1-1.0 % of sliding substances and 2-6% of the said film coating of a pill weight.

EFFECT: method of preparing the solid drug form of trimetazidine dihydrochloride is simple and ensures less time and labour consumption.

2 tbl, 5 ex