HEPATOPROTECTIVE INJECTION PHARMACEUTICAL COMPOSITION ON THE BASIS OF SILIMARINE AND NANOPARTICLES OF SELENIUM Russian patent published in 2018 - IPC B82B1/00 A61K31/95 A61K36/28 A61K47/22 A61K47/12 A61K47/18 A61K47/02 A61P1/16 

FIELD: chemical-pharmaceutical industry.

SUBSTANCE: invention relates to the chemical and pharmaceutical industry and is a hepatoprotective injectable pharmaceutical composition based on silymarin and selenium nanoparticles comprising silymarin, distilled water, characterized that it additionally contains selenium nanoparticles reduced from selenious acid to form colloidal selenium, while cysteine or ascorbic acid or sodium thiosulfate is used as a reducing agent for colloidal selenium, or mercaptoethanol, further comprises, as a pH stabilizer, sodium hydroxide, or potassium hydroxide, or arginine, furthermore contains a stabilizer for silymarin, which is an amber, or fumaric, or apple, or lemon, or oxalic acid.

EFFECT: invention makes it possible to increase the therapeutic activity and bioavailability of the pharmaceutical composition based on silymarin, to reduce the side effects of this drug in therapeutic manipulations.

1 cl, 3 dwg, 3 ex, 1 tbl