SUBSTITUTED THIOPENES, THEIR USING AS MEDICINAL OR DIAGNOSTIC AGENT AND MEDICINAL AGENT COMPRISING THEREOF Russian patent published in 2008 - IPC C07D409/12 A61K31/4168 A61P11/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to synthesis of thiophene of the general formula (I): wherein R1 and R2 mean independently of one another, H, F, Cl, Br, J or -(X)_n-C_qH_2q-Z; n = 0; R3 means hydrogen atom, methyl, F, Cl, Br or J; R4 means hydrogen atom or -C_rH_2r-Y wherein Y means hydrogen atom or trifluoromethyl; R5 and R6 mean hydrogen atom or in common they mean a bond; R7 and R8 mean in common alkylene chain; or R7 and R8 mean in common residue of the formula: ; R10 and R11 mean independently of one another hydrogen atom, fluorine atom, chlorine atom, bromine atom, methyl, -OH, -O-CH₃ or -CF₃; R9 and R12 mean hydrogen atom or F; or one of substitutes in R9 and R12 mean hydrogen atom and another means F, Cl, Br, J, -COOH, -CO-NR13R14 or -(X)_n-C_qH_2q-Z; R13 and R14 in common with nitrogen atoms to which they are bound form saturated 5-, 6- or 7-membered cycle, and their pharmaceutically acceptable salts also. Compounds of the formula (I) possess inhibitory effect on NHE and can be used in treatment of respiration disorders, diseases caused by ischemic and/or reperfusion symptoms and diseases of the central nervous system. Also, invention describes a medicinal agent based on compound of the formula (I) and its using.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and agents.

10 cl, 66 ex