FIVE-MEMBERED HETEROCYCLES WITH BIPHENYLSULFONYL SUBSTITUTION, MEDICINAL AGENT Russian patent published in 2004 - IPC

FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to five-membered heterocycles with biphenylsulfonyl substitution of the formula (I):

wherein R₁ means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; C_aH_2a means phenyl wherein a = 0 that is unsubstituted r substituted with 1-3 substitutes taken among the group consisting of F, Cl, Br, J, CF₃, methoxy-group; C_dH_2d means (C₃-C₇)-cycloalkyl wherein d = 0; R₂ and R₃ means independently of one another hydrogen atom, F, Cl, J, C=N; COR₆ wherein R₆ means hydrogen atom, alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; OR₃₀ wherein R₃₀ means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; OR₇ wherein R₇ means hydrogen atom, alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; phenyl; or R₂ and R₃ mean independently of one another C_qH_2q-phenyl wherein q = 0; or R₂ and R₃ mean independently of one another -SO_nR₂₂ wherein n = 0; R₂₂ means alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, F, Cl, Br, J, CF₃, and to their physiologically acceptable salts also, and to medicinal agents inhibiting Na⁺-dependent Cl^-/HCO-3

EFFECT: valuable medicinal properties of agent.

20 cl, 1 tbl, 36 ex