FIELD: medicine, urology, pharmaceutical industry, pharmacy.
SUBSTANCE: method for correction of PADAM involves oral administration of testosterone or its pharmacologically acceptable derivatives for 22-24 h as a preparative formulation providing onset of release of abovementioned medicinal substance in 4-7 h after its administration, and prolonged effect for 24 h. The testosterone preparative formulation comprises a core and envelope that is insoluble in stomach. A core comprises components in the following ratio, mas. p.: testosterone undecanoate, 1; magnesium basic carbonate, 82-100; sugar, 21.6-26.4; Eudragit E, 2.16-2.64, and calcium stearate, 1.08-1.32. A core is covered by envelope that is difficultly soluble in intestine and providing onset in a medicinal agent releasing in 4-7 h after its administration. Invention provides the testosterone level in a patient that repeats its physiological daily modulation completely. Invention can be used in treatment of patients suffering from partial age androgen deficiency (PADAM) and in production of testosterone preparations or its pharmacologically acceptable derivatives.
EFFECT: improved method of correction of deficiency.
6 cl, 2 tbl, 2 dwg
