MULTI-COMPONENT DOSED PATTERN WITH CONTROLLED ISOLATION OF ACTIVE INGREDIENT Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: every of individual components of a pattern is a mini-tablet of less 5 mm size. All mini-tablets have practically the same size. Mini-tablet consists of a nucleus covered with two membranes. Nucleus contains an active ingredient such as calcitonin or ferritin. One of the membranes is designed from polymer soluble at pH above 5.0. The second membrane is made of practically insoluble polymer, which is permeable for gastrointestinal liquids. Multi-component dosed pattern at pH under the value of 4.5 reveals not higher than 10% calcitonin or ferritin. The rest part of an active ingredient is revealed at pH equal or above 5 during 0.5-8 hours. EFFECT: higher efficiency to provide controlled isolation of active intestinal ingredient. 8 cl