NEW DERIVATIVES OF 1,2,4-THIADIAZOLE AS MODULATORS OF MELANOCORTIN RECEPTOR Russian patent published in 2008 - IPC C07D285/08 C07D417/12 A61K31/433 A61P3/00 A61P17/00 A61P25/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of 1,2,4-thiadiazole of the formula (II): wherein R¹, R² and R⁴ represent radicals comprising cyclic fragments that can be used as agonists or antagonists of melanocortin receptors. Invention provides preparing pharmaceutical compositions comprising the claimed compounds taken in the therapeutically effective dose that can be used in treatment of diseases mediated by melanocortin receptors, for example, such as metabolic disorders, disorders associated with the central nervous system, and dermatological disorders.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

20 cl, 13 tbl, 5 sch, 13 ex