SUBSTITUTED 3-CYANOTIOPHENACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS Russian patent published in 2008 - IPC C07D333/38 C07D333/78 C07D495/04 A61K31/381 A61P3/10 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to substituted 3-cyanotiophenacetamides of general formula I , in which R1 and R2 are independently designate (lower) alkyl, or R1 and R2 together with carbon atoms, to which they are bound, including bond between said carbon atoms, form 5-6 member, unsubstituted carbocyclic or 6-member heterocyclic cycle, probably having substitutes, independently selected from group, including (lower) alkyl, alkylsulfonyl and alkoxycarbonyl, R3 is selected from group, which includes (lower) alkyl, unsubstituted aryl, unsubstituted aralkyl and unsubstituted cycloalkyl, R4 - hydrogen, n is zero, or their pharmaceutically acceptable salts. Compounds can be applied for treatment and/or prevention of diseases, associated with antagonistic action on glucagon receptor, such as diabetes. Pharmaceutical composition based on compounds I and their application are also described.

EFFECT: obtaining substituted 3-cyanotiophenacetamides, which can be applied for treatment and/or prevention of diseases, associated with antagonistic action on glucagon receptor, such as diabetes.

22 cl, 23 ex