DERIVATIVES OF THIOPHENE GLYCOSIDE, MEDICINAL AGENTS COMPRISING THESE COMPOUNDS AND THEIR USING Russian patent published in 2008 - IPC C07H7/00 A61K31/7042 A61P3/10 

FIELD: organic chemistry, medicine, endocrinology.

SUBSTANCE: invention relates to derivatives of thiophene glycoside or their pharmaceutically acceptable salts of the general formula (I): wherein R1 and R2 mean hydrogen atom, (C₁-C₆)-alkyl that can be substituted with fluorine atom, or phenyl; A means (C₀-C₁₅)-alkanediyl wherein one or some carbon atoms can be replaced for -(C=O)-, -CH=CH-, -CH(OH)- or -NH-; n = 0-4; Cyc1 means 5-6-membered unsaturated cycle wherein one carbon atom can be substituted with sulfur atom (S); R3, R4 and R5 means hydrogen atom,, fluorine (F), chlorine (Cl), bromine (Br), iodine (J) atom, -OH, -NO₂, -COOH, -COO-(C₁-C₆)-alkyl, (C₁-C₈)-alkyl, (C₂-C₆)-alkenyl, (C₁-C₁₂)-alkoxy-group, HO-(C₁-C₆)-alkyl, S-(C₁-C₆)-alkyl, -O-(CH₂)₀-phenyl, or R3 and R4 in common with carbon atoms bound with them form 5-7-membered saturated, partially or fully unsaturated cycle Cyc2 and wherein 1 or 2 carbon atoms can be replaced for oxygen atom (O); R⁵ means hydrogen atom. Proposed compounds can be used as anti-diabetic drugs. Also, invention describes a drug based on compounds of the formula (I), a method for its synthesis and using these compounds for preparing a drug used in treatment of diabetes mellitus type 1 and 2.

EFFECT: valuable medicinal properties of compounds and drugs.

14 cl, 58 ex