SULFONYLAMINOCARBOXYLIC ACIDS Russian patent published in 2002 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel sulfonylaminocarboxylic acids of the formula: and/or their stereoisomeric forms and/or physiologically acceptable salts where R¹ means phenyl or phenyl mono- or disubstituted with group C₁-C₆-alkyl-O, halogen atom, trifluoromethyl group, group C₁-C₆-alkyl-O-C(O)-, methylenedioxy-group, R⁴-(R⁵)N-; triazole, thiophene, pyridine; R² means H, C₁-C₆-alkyl; R⁴ and R⁵ are similar of different and mean H, C₁-C₆-alkyl; R³ means H, C₁-C₁₀-alkyl where alkyl is unsubstituted and/or one hydrogen atom of alkyl residue is substituted with hydroxyl-group; C₂-C₁₀-alkenyl; R² means -S(O)_n-C₁-C₆-alkyl where n = 0, 1, 2; R² means S(O)(=NH)-(C₁-C₆)-alkyl and others; or R² and R³ form in common cycle with carboxyl group as substitute of cycle of partial formula (II): where r = 0, 1, 2, 3 and/or one of carbon atom in cycle is substituted with +O-; and/or carbon atom in cycle of partial formula (II) is substituted with phenyl once; A means covalent bond, -O-; B means (CH₂)_m where m = 0; X means +CH=CH- or S. Compounds of the formula (I) are strong inhibitors of matrix metalloproteinases. Compounds of the formula (I) are synthesized from compound of similar structure that has where means R⁸-alkyl, phenyl instead C₁-C₆. EFFECT: valuable biochemical properties of compounds. 4 cl, 2 tbl, 3 ex