FIELD: chemistry.
SUBSTANCE: in substituted aromatic derivatives of formula (Ib) R1 and R2 independently represent H or F, one of R1 or R2 residues must represent F; R3 - OH; A represents O; R4 - hydrogen, (C1-C6)-alkyl, (C1-C6)-alkoxy or OH; R5 -hydrogen, (C1-C6)-alkoxy or halogen; R6 - hydrogen, halogen or OH; B - (C1-C6)-alkandiyl, -CO-NH-CH2-, -O- or -CO-CH2-CH2-; R7 - hydrogen; R8 - hydrogen, OH, (C1-C6)-alkyl, halogen or (C1-C6)-alkoxy, which is optionally single- or multi- substituted with fluorine; R9 - hydrogen; or R8 and R9 together represent -CH=CH-O- or -CH2-CH2-O-,forming together with carbon atoms to which they are bound, Cyc2 -furanyl or dihydrofuranyl, respectively; as well as to their pharmaceutically acceptable salts.
EFFECT: compounds are suitable for preparation of medications for reduction of sugar level in blood.
5 cl, 1 tbl, 25 ex
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Authors
Dates
2008-12-10—Published
2003-11-28—Filed