DNA VACCINE AGAINST PROLIFERATING ENDOTHELIAL CELLS AND USES THEREOF Russian patent published in 2008 - IPC C12N15/12 C12N15/63 A61K48/00 A61P35/00 A61P43/00 

FIELD: medicine.

SUBSTANCE: claimed vaccine includes DNA construct operatively encoding receptor protein of vessel endothelial growth factor (VEGF) selected from group containing VEGFR-2 (KDR; SEQ ID NO:2), VEGFR-1 (Flt-1; SEQ ID NO:4) or Flk-1 (mice KDR homologue, SEQ ID NO:6) and functional equivalent thereof having of about 80 % homology. Encoding receptor proteins of DNA-sequence are represented in SEQ ID NO: 1, 2 and 5, and in description. Described are methods for uses of DNA-vaccines as inhibitors of proliferating endothelial cells in mammalian by administering of DNA-vaccine to stimulate of immune response in relation to proliferating endothelial cells, in particular to inhibit angiogenesis and tumor growth. Also disclosed is dosage form of DNA-vaccine.

EFFECT: DNA-vaccine against angiogenesis and tumor growth.

14 cl, 13 dwg, 5 tbl, 4 ex