FIELD: biotechnology.
SUBSTANCE: invention relates to an attenuated mutant Salmonella enterica Serovar Typhi Tu21a strain and a vaccine containing such a strain. The present strain contains, at least, one copy of a recombinant DNA molecule that contains a eukaryotic expression cassette encoding VEGF protein receptors, wherein the VEGF receptor protein is human VEGFR-2, which has an amino acid sequence as set forth in SEQ ID NO: 1 for use as a vaccine in immunotherapy of malignant tumours, where a single dose of the vaccine is 1×109 or less than 1×109 CFU.
EFFECT: inventions allows to obtain necessary immunological and clinical responses at very low doses.
16 cl, 12 dwg, 2 tbl, 7 ex
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