FIELD: medicine, pharmaceutical technology, hormones.
SUBSTANCE: invention describes a method for preparing isotonic oily emulsions containing estradiol and progesterone in the ratio from 2:1 to 200:1 and wherein the emulsion comprises 0.005-0.5 wt.-% of estradiol and 0.05-5 wt.-% of progesterone, and this emulsion is designated for intravenous administration. Method for preparing such emulsions involves the following steps: (A) dissolving at least one hormone, i. e. estradiol or progesterone in oily phase, and (B) emulsifying oily phase in aqueous phase in the presence of an emulsifying agent. Emulsions prepared by this method under condition of minimal supply of oil and volume (liquid) result to the higher concentrations of hormones in premature baby blood.
EFFECT: improved and valuable pharmaceutical properties of emulsion.
6 cl, 2 tbl, 1 dwg, 2 ex
