D-CYCLOSERINE-BASE DRUG, NANOPARTICLES-CONTAINING PREPARATION OF PROLONGED EFFECT, METHOD FOR ITS PREPARING Russian patent published in 2008 - IPC A61K31/42 A61K9/14 A61P31/06 

FIELD: medicine, pharmacology, pharmaceutical technology, pharmacy.

SUBSTANCE: invention relates to a new generation of antibacterial preparations based on D-cycloserine that comprises nanoparticles and possessing the regulated effect. Method for preparing this preparation involves heating an agent containing a mixture consisting of D-cycloserine, PLGA 50/50, D-mannitol, polysorbate-80 and dimethylsulfoxide taken in the definite ratio at temperature 50-60^oC to obtain uniform clear liquid followed by its cooling to room temperature, dilution with water, and formed suspension containing nanoparticles of size 3.0 ± 0.5 nM (˜20% of the total amount of particles) and ˜200 nM (˜80% of the total amount of particles) are used by designation. Invention provides preparing the preparation possessing high antibacterial activity, prolonged effect, relative harmless and low toxicity.

EFFECT: improved preparing method, improved and valuable medicinal properties of agent.

3 cl, 4 tbl, 5 ex