D-CYCLOSERIN-BASED MEDICATION OF PLOLONGED ACTION WITH DOSED RELEASE IN TARGET ORGANS FOR TREATMENT OF RESISTANT FORMS OF TUBERCULOSIS Russian patent published in 2010 - IPC A61K31/42 A61K9/14 A61P31/06 B82B1/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of pharmacology and medicine, namely to new generation of antimicrobial D-cycloserin-based medications of regulated action. Described is medication of anti-microbial action with prolonged release into target organs, characterised in that it represents stable nanoparticles and includes D-cycloserin, PLGA 50/50, D-mannit and polyvinyl alcohol, with the following component ratio, wt %: D-cycloserin from 1 to 15; PLGA 50/50 from 20 to 40; D-mannit from 5 to 40; polyvinyl alcohol from 5 to 15. Described medication has considerably lower neurotoxicity and is able to produce bactericidal effect with respect to Mycobacterium tuberculosis, without producing toxic effect and possessing high therapeutic efficiency.

EFFECT: application of elaborated medication allows to achieve highly selective dosed release of active substance into target organs-cells (macrophages).

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