FIELD: pharmacology.
SUBSTANCE: drug comprises, wt %: niclosamide - 3.6-6.5, copolymer of lactic and glycolic acid at a monomer unit molar ratio of 50:50 - 31.8-53.6, Eudragit RS PO or Eudragit RL PO - 10.4-34.9, surfactant, such as polyvinyl alcohol - 9.8-28.8, cryoprotectant, such as D-mannitol - 7.1-13.5.
EFFECT: reduced systemic toxicity and prolonged niclosamide release.
2 cl, 1 dwg, 3 tbl, 6 ex
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