AZAHETEROCYCLES, COMBINATORY LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING (VARIANTS) Russian patent published in 2008 - IPC C07D243/06 C07D241/36 C07D241/06 C07D245/04 C07D245/02 C07D255/04 C07D283/00 C07D223/10 C07D487/04 C07D491/04 C07D491/48 C07D493/04 C07D513/04 C07D498/04 C07D281/08 C07D267/14 A61K31/5395 A61K31/381 A61K31/551 A61K31/553 A61K31/554 A61P35/00 C40B40/04 

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to novel azaheterocycles of the general formula (I): possessing inhibitory effect on activity of tyrosine kinase and can be used in treatment of different diseases mediated by these receptors. In compound of the general formula (1) W represents azaheterocycle comprising 6-13 atoms that can be optionally annelated with at least one (C₅-C₇)-carbocycle and/or possibly annelated with heterocycle comprising 4-10 atoms in ring and comprising at least one heteroatom chosen from oxygen (O), sulfur (S) or nitrogen (N) atom; R^a ₁ represents a substitute of amino group but not hydrogen atom, such as substituted (C₁-C₆)-alkyl, possibly substituted aryl and possibly substituted 5-10-membered heterocyclyl comprising at least one heteroatom chosen from O, S or N; R^b represents carbamoyl group -C(O)NHR^a wherein R^a represents a substitute of amino group but not hydrogen atom, such as possibly substituted alkyl, possibly substituted aryl, possibly substituted 5-10-membered heterocyclyc comprising at least one heteroatom chosen from O, S or N; R^c represents a substitute of cyclic system, such as possibly substituted (C₁-C₆)-alkyl, possibly substituted aryl and possibly substituted 5-6-membered heterocyclyl comprising at least one heteroatom chosen from O, S or N; or R^b and R^c form in common aminocyanomethylene group [(=C(NH₂)CN], or their pharmaceutically acceptable salts. Also, invention relates to methods for synthesis of these compounds (variants), a pharmaceutical composition, combinatory and focused libraries.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved methods for synthesis and preparing.

35 cl, 16 sch, 13 tbl, 43 ex