AZAHETEROCYCLES, COMBINATORIAL LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINING Russian patent published in 2009 - IPC C07D471/04 C07D273/01 C07D495/04 A61K31/4745 A61K31/381 A61P35/00 

FIELD: chemistry, pharmaceutics.

SUBSTANCE: claimed invention relates to novel azaheterocycles of general formula 1.1-13 and 2, as well as their pharmaceutically acceptable salts, which possess anti-carcinogenic activity, pharmaceutical composition with their application and combinatorial and focused libraries including novel azaheterocycles. In general formulae 1.1-1.3 and 2.

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For compounds 1.1-1.3 each of R₁ ^a R₂ ^a independently on each other represent possibly substituted C₁-C₆alkyl; each of R₁ ^d, R₂ ^d, R₃ ^d, R₄ ^d, R₅ ^d, R₆ ^d and R₇ ^d independently on each other represent substitutes of cyclic system, preferably hydrogen atom, or for compounds 1.1 and 1.3 independently R₁ ^d and R₂ ^d, R₃ ^d and R₄ ^d, R₅ ^d and R₆ ^d together with atoms with which they are bound can form through R₁ ^d and R₂ ^d, R₃ ^d and R₄ ^d, R₅ ^d and R₆ ^d respectively, possibly substituted aromatic cycle, such as benzole, 5-6-member heterocycle which includes, at least, one of heteroatoms, selected from S; or for compounds 1.2 independently R₁ ^d and R₂ ^d, R₃ ^d and R₄ ^d, R₄ ^d and R₅ ^d, R₆ ^d and R₇ ^d together with atoms with which they are bound can form through R₁ ^d and R₂ ^d, R₃ ^d and R₄ ^d, R₄ ^d and R₅ ^d, R₆ ^d and R₇ ^d respectively, possibly substituted aromatic cycle, such as benzole, 5-6-member heterocycle which includes, at least, one of heteroatoms, selected from S; for compound 2 R₁ ^a represents amino group substitute, excluding hydrogen atom, such as possibly substituted C₁-C₆alkyl, possibly substituted phenyl; R₂ ^a represents possibly substituted C₁-C₆alkyl; R₃ ^a represents amino group substitute, such as hydrogen atom, possibly substituted C₁-C₆alkyl; R_n ^d represents one or two substitutes of cyclic system, preferably hydrogen atom, solid line with accompanying it dotted line represent single or double bond.

EFFECT: obtaining novel azaheterocycles and their pharmaceutically acceptable salts, which possess anti-carcinogenic activity.

9 cl, 4 dwg, 3 tbl, 7 ex