ANELLATED CARBAMOYL AZAHETEROCYCLES, METHODS FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION, FOCUSED LIBRARY Russian patent published in 2005 - IPC

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to new anellated carbamoyl azaheterocycles of the general formula (1)

or (2) possessing the inhibitory effect on protein kinase activity, a focused library comprising these compounds, and pharmaceutical composition based on thereof. In the general formula (1) or (2) R¹ represents hydrogen atom or optionally substituted (C₁-C₆)-alkyl; R² and R³ represent independently of one another hydrogen atom, inert substitute, optionally substituted (C₁-C₆)-alkyl, optionally substituted (C₃-C₈)-cycloalkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted heterocyclyl; R⁴ represents optionally substituted (C₁-C₆)-alkyl, optionally substituted (C₃-C₈)-cycloalkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted heterocyclyl; A and B in common with carbon and nitrogen atoms joined to the form an optionally substituted and optionally condensed azaheterocycle; D and F in common with carbon atoms joined form an optionally substituted and optionally condensed phenyl or aryl, optionally substituted and optionally condensed azaheterocycle. K and L in common with carbon and nitrogen atoms joined to them form an optionally substituted azaheterocycle. Also, invention related to methods for preparing compounds of the general formulae (1) or (2).

EFFECT: improved preparing methods.

10 cl, 2 sch, 25 tbl, 7 ex