DERIVATIVES OF HYPERFORIN, THEIR USING AND COMPOSITIONS CONTAINING THEREOF Russian patent published in 2008 - IPC C07C49/733 C07C49/743 C07C69/13 A61K31/122 A61P25/28

Abstract RU 2320636 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of hyperforin and adhyperforin of the formula (I): wherein R represents methyl or ethyl; R₂ represents hydrogen atom, lithium or dicyclohexyl ammonium cation, direct or branched (C₂-C₅)-acyl residue wherein alternatively: (a) R₁ represents 3-methylbut-1-yl, and oxo groups are in 1- and 10-positions; (b) R₂ represents 3-methyl-2-butene-1-yl, and hydroxy groups are in 1- and 10-positions; (c) R₁ represents 3-methylbut-1-yl, and hydroxy groups are in 1- and 10-positions. Compounds are used in preparing drugs for using in treatment of depression and Alzheimer's disease. Also, invention describes a pharmaceutical composition possessing anti-depressant effect.

EFFECT: valuable medicinal properties of substances and pharmaceutical composition.

8 cl, 2 tbl, 6 ex

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RU 2 320 636 C2

Authors

Bombardelli Ehtsio

Moratstsoni Paolo

Riva Antonella

Fudzati Nikola

Dates

2008-03-27—Published

2003-04-18—Filed