DERIVATIVES OF TETRAHYDROPYRANE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new compounds of the formula (I) where R₁ means a group of the formula (1a) or (1b) where R₇ means optionally substituted hydroxy-group, acyloxy-group, halogen atom, -OR₁₀ where R₁₀ means lower alkyl optionally substituted with -O(CH₂)_mOH where m is a number from 2 to 4 or -OCONH₂; R_7a means hydrogen atom; or R₇ and R_7a mean oxo-group; R₈ means hydroxy- or methoxy-group and R₉ means hydroxy- or acyloxy-group; R₂ means hydrogen atom, acyloxy- -group or optionally substituted hydroxy-group; between two carbon atoms bound with dotted line - a simple or double bond exists; R₃ means methyl, ethyl, n-propyl or allyl; or R₄ means hydrogen atom or hydroxy-group and R_4a means hydrogen atom; or R₄ and R_4a mean oxo-group; or R₅ means hydroxy-group and R_5a means hydrogen atom; or R₅ and R_5a/ mean oxo-group; A means a group of the formula -CH(OR₆)-CH₂-(CH₂)_n or -CH= CH-(CH₂)_n- bound with carbon atom through (CH₂)_n-; R₆ means lower alkyl and n = 1 or 2. Compounds can be in free form or as salts. These compounds are used as pharmaceutical preparations, especially as anti-inflammatory and antiprofilerative agents. EFFECT: enhanced effectiveness of compounds as curative agents. 9 cl, 4 tbl, 36 ex