FIELD: medicine, endocrinology, chemical-pharmaceutical industry.
SUBSTANCE: invention relates to a pharmaceutical composition used in treatment and prophylaxis of osteoporosis and for effective administration of parathyroid hormone fragments (PTH) (1-28) - (1-14). Also, invention relates to a method for oral administration of indicated composition and to a method for stimulation of osseous tissue formation in osteoporosis, to a method for treatment or prophylaxis of osteoporosis, and to using 5-CNAC for preparing pharmaceutical composition containing fragments PTH (1-28) - (1-14) used for treatment or prophylaxis of osteoporosis. The claimed invention provides achievement of higher blood concentrations of PTH fragments (1-28) - (1-14) and to retain these concentrations for a longer time. Using 5-CNAC as a component of the composition allows carrying out oral administration of PTH fragments.
EFFECT: improved and valuable properties of agent.
21 cl, 2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION | 2006 |
|
RU2469709C2 |
| ORAL ADMINISTRATION OF PARATHYROID HORMONE AND CALCITONIN | 2002 |
|
RU2300392C2 |
| CRYSTALLINE FORMS OF DISODIUM SALT OF N-(5-CHLOROSALICILOUL-)-8-AMINOCAPRYLIC ACID | 2006 |
|
RU2507196C2 |
| CALCITONIN USED AT OSTEOARTHRITIS | 2004 |
|
RU2368390C2 |
| PERORAL INTRODUCTION OF CALCITONIN | 2003 |
|
RU2355417C2 |
| PHARMACEUTICAL COMPOSITIONS FOR PERORAL INTAKE OF PHARMACOLOGICAL ACTIVE SUBSTANCES | 2001 |
|
RU2287999C2 |
| APPLICATION OF CALCITONIN FOR TREATING RHEUMATOID ARTHRITIS | 2006 |
|
RU2453330C2 |
| PHARMACEUTICAL COMPOSITIONS CONTAINING HGH FOR ORAL ADMINISTRATION | 2007 |
|
RU2493868C2 |
| PARATHYROID HORMONE ANALOGUES FOR OSTEOPOROSIS TREATMENT | 1997 |
|
RU2203286C2 |
| METHOD FOR INTRODUCING BISPHOSPHONATES | 2001 |
|
RU2288722C2 |
