ANTIGEN MATRIX FOR TREATMENT OF BONE DISEASE Russian patent published in 2008 - IPC A61K39/39 A61K39/385 A61K38/19 A61P19/00 

FIELD: medicine, virology, immunology, molecular biology.

SUBSTANCE: invention involves a composition comprising a regulated and repeated matrix of antigens or antigen determinants and, in particular, matrix comprising RANKL protein, RANKL fragment or RANKL-VLP peptide. Invention relates to a composition comprising viral-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound with its, and to a method for preparing conjugates and regulated and repeated matrices, respectively. Proposed compositions can be used for preparing vaccines used in treatment of bone diseases and as a pharmaceutical vaccine used for prophylaxis or treatment of bone diseases, and for effective induction of immune responses, in particular, humoral responses. The advantage of invention involves enhancing induction of immune responses to RANKL protein.

EFFECT: valuable biological and medicinal properties of matrices.

28 cl, 7 dwg, 20 ex