HISTONE DEACETYLASE INHIBITOR-CONTAINING PHARMACEUTICAL COMPOSITION Russian patent published in 2008 - IPC A61K31/165 A61K31/4406 A61P35/00 

Abstract RU 2322971 C2

FIELD: organic chemistry, medicine, pharmacology, biochemistry.

SUBSTANCE: invention relates a pharmaceutical composition, pharmaceutical combination and a set for treatment of cancer forms mediated by histone deacetylase. Proposed composition and combination comprises the effective amount of benzamide derivatives of the formula (5): and other anticancer active substance chosen from group consisting of cisplatin, etoposide, camptothecin, 5-fluorouracil, gemcitabine, paclitaxel, docetaxel, carboplatin, oxaplatin, doxorubicin and vinblastine. Invention provides high effectiveness of treatment and decreasing toxicity.

EFFECT: valuable medicinal properties of pharmaceutical composition, enhanced effectiveness of treatment.

106 cl, 13 tbl, 1 dwg

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RU 2 322 971 C2

Authors

Nakanisi Osamu

Sugavara Tatsuo

Migita Khidejuki

Matsuba Jasukhiro

Dates

2008-04-27Published

2004-05-26Filed