FIELD: organic chemistry, medicine, pharmacology, biochemistry.
SUBSTANCE: invention relates a pharmaceutical composition, pharmaceutical combination and a set for treatment of cancer forms mediated by histone deacetylase. Proposed composition and combination comprises the effective amount of benzamide derivatives of the formula (5): and other anticancer active substance chosen from group consisting of cisplatin, etoposide, camptothecin, 5-fluorouracil, gemcitabine, paclitaxel, docetaxel, carboplatin, oxaplatin, doxorubicin and vinblastine. Invention provides high effectiveness of treatment and decreasing toxicity.
EFFECT: valuable medicinal properties of pharmaceutical composition, enhanced effectiveness of treatment.
106 cl, 13 tbl, 1 dwg
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Authors
Dates
2008-04-27—Published
2004-05-26—Filed