FIELD: medicine.
SUBSTANCE: group of inventions relates to the treatment of cancer. The use of a combination is disclosed, where the combination contains: metformin or phenformin, or their pharmaceutically acceptable salt; 2-deoxy-D-glucose; inositol hexaphosphate or its pharmaceutically acceptable salt, inositol, or a mixture thereof, for the production of a drug for the treatment of cancer. In this case, the mass ratio of metformin or its pharmaceutically acceptable salt : 2-deoxy-D-glucose : inositol hexaphosphate or its pharmaceutically acceptable salt, or inositol is from 1:0.2:0.5 to 1:5:20, phenformin or its pharmaceutically acceptable salt : 2-deoxy-D-glucose : inositol hexaphosphate or its pharmaceutically acceptable salt or inositol is from 1:1:1 to 1:50:200, metformin or its pharmaceutically acceptable salt : 2-deoxy-D-glucose : inositol hexaphosphate or its pharmaceutically acceptable salt : inositol is from 1:0.2:0.5:0.5 to 1:5:20:20, or phenformin or its pharmaceutically acceptable salt : 2-deoxy-D-glucose : inositol hexaphosphate or its pharmaceutically acceptable salt : inositol is from 1:1:1:1 to 1:50:200:200. A method for the treatment of cancer, the use for the treatment of cancer of a pharmaceutical composition, and a combination for the treatment of cancer are also disclosed.
EFFECT: group of inventions provides a synergetic anticancer effect.
12 cl, 12 dwg, 9 ex
Authors
Dates
2023-01-31—Published
2019-11-11—Filed