HETERO-ARYL SUBSTITUTED DERIVATIVES OF AMIDAZOLE AS ANTAGONISTS OF GLUTAMATE RECEPTORS Russian patent published in 2008 - IPC C07D403/04 C07D401/04 C07D405/04 C07D417/14 A61K31/4439 A61K31/496 A61K31/497 A61P25/28 A61P25/04 A61P7/12 

FIELD: chemistry; obtaining of medicinal preparations.

SUBSTANCE: description is given of a compound with general formula where R¹ represents a halogen, C₁-C₆alkyl, CF₃, CF₂H or cyano, R² represents C₁-C₆alkyl, R³ represents 5- or 6 - member hetero-aryl, optionally substituted with one, two or three substitutes, chosen from a group, consisting of a halogen, C₁-C₆alkyl, C₃-C₆cycloalkyl, C₁-C₆alkylhalogen, C₁-C₆alkoxy, NR'R", or substituted with a 1-morpholinyl group or substituted with thiomorpholinyl groups, 1-oxothiomorpholinyl or 1,1-dioxothiomorpholinyl; R', R" independently represent hydrogen, C₁-C₆alkyl, (CH₂)_0,1-(C₃-C₆)cycloalkyl, R represents hydrogen as well as its pharmaceutical salts and the method of obtaining them. The invention also relates to use of the given amidazole derivatives for obtaining medicinal preparations and to medicinal preparations containing them, meant for prevention or treatment of damages, through the mGluR5 receptor, such as acute and/or chronic neurologic damages, primarily shock pain, or for treatment of chronic and sharp pain.

EFFECT: obtaining of new compounds, with useful biological properties.

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