FIELD: chemistry; medicine.
SUBSTANCE: in general formula I 
R1 stands for haloid, lower alkyl; R2 stands for lower alkyl or C3-C6-cycloalkyl; R3 stands for lower alkyl, C3-C6-cycloalkyl, -(CH2)n-C3-C6-cycloalkyl, (CH2)n-CN or -(CH2)n-O-(lower)alkyl, (lower)alkoxyaryl, Fn-R5, where R5 is lower alkyl or lower alkenyl; n takes values 1, 2 or 3; R4 is hydrogen or CH2R5, where R5 is hydrogen, C1-C6-alkyl, C3-C12-cycloalkyl; as well as its pharmaceutically acceptable salts. Invention also relates to methods of obtaining formula I compounds, medication based on formula I compound and its application.
EFFECT: obtained are novel imidazole derivatives, useful in treatment or prevention of disorders mediated by activity of glutamate receptor mGluR5.
18 cl, 31 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMIDAZOL DERIVATIVES, METHOD OF THEIR OBTAINING AND THEIR APPLICATION, MEDICATION | 2004 |
|
RU2345074C2 |
| HETERO-ARYL SUBSTITUTED DERIVATIVES OF AMIDAZOLE AS ANTAGONISTS OF GLUTAMATE RECEPTORS | 2004 |
|
RU2327697C2 |
| IMIDAZOLE DERIVATIVES AS mGluR5 ANTAGONISTS | 2010 |
|
RU2527106C2 |
| DERIVATIVES OF BENZO {b} {1, 4} DIOXEPIN | 2004 |
|
RU2350610C2 |
| ARYLETHINYL DERIVATIVES | 2011 |
|
RU2573560C2 |
| PHENYLETHENYL- OR PHENYLETHYNYL-DERIVATIVES AS ANTAGONISTS OF GLUTAMATE RECEPTORS | 2001 |
|
RU2284323C9 |
| INDOLIN-2-ONE OR PYRROLO-PYRIDIN/PYRIMIDIN-2-ONE DERIVATIVES | 2014 |
|
RU2666532C2 |
| DERIVATIVES OF N-(IMIDAZOPYRIMIDIN-7-YL)-HETEROARYLAMIDES AND THEREOF APPLICATION AS PDE10A INHIBITORS | 2011 |
|
RU2562066C2 |
| DERIVATIVES OF PYRIDINE AND MEDICINAL AGENT BASED ON THEREOF POSSESSING SELECTIVE BLOCKING ACTIVITY WITH RESPECT TO SUBSPECIES OF NMDA-RECEPTORS | 2002 |
|
RU2303037C2 |
| INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES | 2015 |
|
RU2697512C2 |
