PYRIDINONE AND PYRIDAZINONE DERIVATIVES Russian patent published in 2017 - IPC C07D213/64 C07D237/14 C07D401/04 C07D401/10 C07D401/12 C07D401/14 C07D403/04 C07D403/10 C07D403/12 C07D405/04 C07D405/12 C07D413/10 C07D417/04 A61K31/435 A61K31/50 A61K31/501 A61K31/5377 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of formula (I) or its pharmaceutically acceptable salts: , wherein J is a group of formula IIa, R^1a is C₁-C₃alkyl; Y^1a is N or CR^xa, where R^xa is H, X^2a is selected from the group consisting of: H, C₁-C₄alkyl; X^1a is selected from the group consisting of: hydrogen, halogen, C₁-C₆alkyl, C₁-C₄haloalkyl,-O-C₁-C₄alkyl, -O-C₁-C₃alkylene-C₃-C₇cycloalkyl, -O-C₁-C₄haloalkyl, -O-C₁-C₃alkylene(5-membered heterocycloalkyl having 1 heteroatom selected from O), -O-C₁-C₆alkylene-N(R¹⁰)₂, -O-C₁-C₃alkylene-C(O)OC₁-C₄alkyl, -C₂-C₄alkenylene-C(O)-O-C₁-C₄alkyl, -C(O)-C₁-C₄alkyl, C(O)O-C₁-C₄alkyl, C(O)NR¹⁰R¹², -NR¹⁰-C₁-C₃alkylene-C(O)-C₁-C₄alkyl, -SO₂NR¹⁰R¹² and any of the groups: ii) 6-membered heterocycloalkenyl, which may be substituted with 1 R²; iii) 5-6 membered heterocycloalkyl with 1 to 2 heteroatoms selected from N, which may be substituted with 1-2 R³; iv) 5-6 membered heteroaryl with 1-3 heteroatoms independently selected from N, O, 9-10 membered bicyclic heteroaryl with 1 to 3 heteroatoms independently selected from N, S, which may be substituted with 1-2 R⁴; v) phenyl which may be substituted with 1-2 R⁶; X³ is LG where L is absent or is selected from the group consisting of: -O-, -O-C₁-C₃alkylene; and G is selected from the group consisting of: phenyl, 6-membered heteroaryl with 1 heteroatom selected from N, 9-membered bicyclic heteroaryl with 2 heteroatoms, selected from N, C₃-C₇cycloalkyl, 6-membered heterocycloalkyl with 1 heteroatom selected from N, O, where G may be substituted with 1-2 groups, A² is CR¹⁸, and A¹, A³ and A⁴ are CR¹⁹, values of the remaining substituents are indicated in the claims. The invention also relates to individual compounds, to a pharmaceutical composition and to a method for cancer treatment.

EFFECT: new compounds with proliferative activity are obtained.

20 cl, 6 tbl, 293 ex