NUCLEOSIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION, WITH ANTIVIRAL ACTIVITY TO HCV Russian patent published in 2008 - IPC C07H19/67 A61K31/7068 A61P31/14 

FIELD: chemistry; medicine.

SUBSTANCE: invention pertains to nucleoside derivatives with general formula (I) , where R¹ represents hydrogen; COR⁵, where R⁵ is chosen from C_1-18 alkyl, phenyl, CH₂OPh and CH₂Ph; C(=O)OR⁵, where R⁵ represents C_1-18 alkyl; or COCH(R⁶)NHR⁷, where R⁶ represents C_1-5 alkyl, and R⁷ represents R⁵OCO, where R⁵ is C_1-18 alkyl, R² represents hydrogen; COR⁵ , where R⁵ is chosen from C_1-18 alkyl, C_1-18 alkenyl, phenyl or CH₂OPh; C(=O)OR⁵, where R⁵ is chosen from C_1-18 alkyl, C_1-18 alkenyl, substituted with low alkyl; C(=O)NHR⁵, where R⁵ represents C_1-18 alkenyl; or COCH(R⁶)NHR⁷, where R⁶ is chosen from side-chains of natural amino acid and C_1-5alkyl, and R⁷ is chosen from hydrogen and R⁵OCO, where R⁵ is C_1-18 alkyl; R³ and R⁴ are the same and are chosen from hydrogen; COR⁵, where R⁵ is chosen from C_1-18 alkyl, or phenyl; C(=O)OR⁵, where R⁵ is C_1-18 alkyl, or R³ and R⁴ together represent C(CH₃)₂; or their pharmaceutical acidic additive salts; under the condition that, at least one of R¹, R², R³ or R⁴ is not hydrogen. The invention also relates to pharmaceutical compositions, which have antiviral activity to HCV.

EFFECT: obtaining of a range of new biologically active substances.

15 cl, 2 tbl, 9 ex