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2 736 217

(13)

(51)

IPC

C07D487/04(2006-01-01)

C07D519/00(2006-01-01)

A61K31/407(2006-01-01)

A61P7/00(2006-01-01)

(21) (22)

Application

2019137023, 2018-03-20

(24)

Start date

2018-03-20

(22)

Actual filing date

2018-03-20

(45)

Published

2020-11-12

(72)

Inventor

Eriksson, AnnaGrin, NilGustafson, GariKhan, BinsunLanchia, Ml. Devid R.Mitchell, LornaRichard, DevidShelekhin, TatyanaSmit, Chejz K.Van, ChzhungoChzhen, Syaochzhan

(73)

Holder

Forma Therapeutics, Inc.

PYRROLO-PYRROLE COMPOSITIONS AS ACTIVATORS OF PYRUVATE KINASE (PKR) Russian patent published in 2020 - IPC C07D487/04 C07D519/00 A61K31/407 A61P7/00

Abstract RU 2736217 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a pharmaceutical composition having pyruvate kinase (PKR) activator activity containing an effective amount of a compound of formula I, where values of R¹-R¹¹, R^1'-R^11', Y are specified in the claim.

EFFECT: pharmaceutical composition is intended for treating diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase (PKD) insufficiency, sickle cell disease (SCD) and thalassemia.

24 cl, 1 dwg, 7 tbl, 46 ex

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RU 2 736 217 C2

Authors

Eriksson, Anna

Grin, Nil

Gustafson, Gari

Khan, Binsun

Lanchia, Ml. Devid R.

Mitchell, Lorna

Richard, Devid

Shelekhin, Tatyana

Smit, Chejz K.

Van, Chzhungo

Chzhen, Syaochzhan

Dates

2020-11-12—Published

2018-03-20—Filed