METHOD OF OBTAINING 5- HALOGENALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES Russian patent published in 2014 - IPC C07D261/04 C07C69/76 C07C233/65 C07C49/813 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining a compound of formula , where R¹ represents CHX₂, CX₃, CX₂CHX₂ or CX₂CX₃; each X independently represents Cl or F; Z represents phenyl, optionally substituted with one or more substituents, independently selected from R²; and each R² independently represents halogen, C₁-C₆ alkyl or C₁-C₆ halogenalkyl; Q represents Q^b; Q^b represents 1-naphthalenyl, optionally substituted with R³; each R³ independently represents halogen, C₁-C₆ alkyl, C₁-C₆ halogenalkyl, -C(=W)N(R⁴)R⁵ or-C(=W)OR⁵; each R⁴ represents H; each R⁵ represents H or C₁-C₆ alkyl, optionally substituted with R⁶; each R⁶ represents C₂-C₇ alkylaminocarbonyl or C₂-C₇ halogenalkylaminocarbonyl; and each W independently represents O; including the stage, at which a compound of formula , where R¹, Q and Z are determined before for the formula 1 compound, contacts with hydroxylamine in the presence of a base. Hydroxylamine is obtained from the hydroxylamine salt. The base includes one or more compounds, selected from amine bases, hydroxide bases of alkali metals, alkoxide bases of alkali metals and carbonate bases of alkali metals. The invention also relates to the formula 2 compound, N-oxides and their salts, and such a particular compound as 4-acetyl-1-naphthalenecarbonyl chloride.

EFFECT: novel enones of formula, applied as initial materials for obtaining 5-halogenalkyl-4,5-dihydroisoxazoles.

15 cl, 14 tbl, 8 ex