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(19)

(11)

2 328 486

(13)

(51)

IPC

C07D211/86(2006-01-01)

C07D239/22(2006-01-01)

A61K31/4412(2006-01-01)

A61K31/505(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2005113168/04, 2003-11-11

(24)

Start date

2003-11-11

(22)

Actual filing date

2003-11-11

(45)

Published

2008-07-10

(72)

Inventor

Blad KhokanKlingstedt TomasLarsson JoakimLavits KarolinaLepiste MattiLenn KhansNikitidis Grigorios

(73)

Holder

Astrazeneka Ab

2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE Russian patent published in 2008 - IPC C07D211/86 C07D239/22 A61K31/4412 A61K31/505 A61P29/00

Abstract RU 2328486 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the 2-pyridone derivatives with the common formula where X, Y¹, R¹, Y², G¹, R⁵, R⁴, L, G² are as specified in the invention formula. The invention also relates to the pharmaceutical agent which inhibits the human neutrophil elastase activity and which contains the compound with the formula (I), in drug manufacturing, and to the method of producing the compound with formula (I).

EFFECT: producing novel compounds which inhibit neutrophil elastase activity.

8 cl, 1 tbl, 96 ex

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RU 2 328 486 C2

Authors

Blad Khokan

Klingstedt Tomas

Larsson Joakim

Lavits Karolina

Lepiste Matti

Lenn Khans

Nikitidis Grigorios

Dates

2008-07-10—Published

2003-11-11—Filed