2-PYRAZINONE DERIVATIVES FOR TREATING DISEASES OR CONDITIONS WHERE INHIBITING NEUTROPHIL ELASTASE ACTIVITY IS USEFUL Russian patent published in 2012 - IPC C07D241/24 C07D401/14 C07D403/04 C07D403/14 A61K31/497 A61P1/04 A61P11/00 A61P11/06 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula where R¹ denotes C₁-C₆alkyl; W denotes pyrazolyl, triazolyl or imidazolyl; R¹⁴ denotes phenyl or a 6-member heteroaromatic ring containing 1-3 nitrogen ring atoms, which is may be substituted with at least one substitute selected from F, Cl, CN and CF₃; R³ denotes phenyl, substituted with a trifluoromethyl substitute; R4 denotes hydrogen or C₁-C₆alkyl; X denotes -C₁-C₆alkylene-Y-, and Y denotes a single bond, and the alkylene group is a straight or branched C₁-C₆alkylene, possibly substituted with OH, CO₂R⁶⁶ or C₁-C₃alkoxy; R⁵ denotes phenyl or pyridinyl, substituted with -S(O)_vR²¹; or R⁵ denotes an unsubstituted C₃-C₆cycloalkyl ring; or R⁵ can also denote H; R²¹ denotes hydrogen, C₁-C₆alkyl or C₃-C₈cycloalkyl; v equals 1 or 2; and R⁶⁶ denotes hydrogen or C₁-C₆alkyl; or pharmaceutically acceptable salts thereof. The invention also relates to a method of producing said compounds, intermediate compounds and a pharmaceutical composition for treating or reducing the risk of disease or condition, in which inhibiting neutrophil elastase activity based on compounds of formula (I) is useful.

EFFECT: obtaining novel compounds which can be used in medicine to treat or reduce the risk of disease or condition in which inhibiting neutrophil elastase activity is useful.

19 cl, 16 ex