2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR APPLICATION Russian patent published in 2009 - IPC C07D211/86 C07D401/04 C07D401/06 C07D405/04 C07D405/06 C07D417/04 C07D409/04 C07D409/06 C07D413/04 C07D413/06 A61K31/4412 A61K31/443 A61K31/4436 A61K31/4439 A61K31/444 A61P29/00 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to compounds of formula (I), their obtaining and application as elastase inhibitors, and can be applied in medicine, where Y = CH; R№ represents H or alkyl; RІ represents phenyl or 5-6-memner heteroaryl, G¹ represents phenyl; R⁵ represents H, halogen, alkyl, CN or fluorinated alkyl; n=1-3; R⁴ = H; L represents bond, O, NR²⁹ or alkyl; or R⁴ and L are bound together in such way that group -NR⁴L- represents 5-7-member asacyclic ring; G² represents phenyl, 5-6-member heteroaryl, cycloalkyl, C_4-7-heterocycle, bicycle from two condensed, bound with direct bond or separated with O atom rings, selected from phenyl, 5-6-member heteroaryl, cycloalkyl or C_4-7-heterocycle; or when L does not represent bond, G² represents H; s = 0-2; R²⁵ represents H, alkyl or cycloalkyl; R²⁹ represents H or alkyl.

EFFECT: obtaining novel biologically active compounds.

10 cl, 95 ex, 1 tbl