TETRAHYDROQUINOLIN DERIVATIVES, BASED ON THEM PHARMACEUTICAL COMPOSITION AND THEIR APPLICATION AS FERTILITY REGULATOR Russian patent published in 2008 - IPC C07D215/38 C07D403/12 C07D407/12 C07D413/12 A61K31/47 A61P5/08

Abstract RU 2328487 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the tetrahydroquinolin derivatives with the common formula (I) , or their pharmaceutically acceptable salts, where R¹ and R² are H, Me; R³ is (2-6C)-hetercycloalkyl(1-4C)alkyl, (2-5C)heteroaryl(1-4C)alkyl, (6C)aryl(1-4C)-alkyl, (2-6C)hetercycloalkylcarbonylamino(2-4C)alkyl, R⁵-(2-4C)alkyl or R⁵-carbonyl(1-4C)alkyl; R⁴ is (2-5C)heteroaryl (6C)aryl, not necessarily substituted with one or more substitutes selected from bromine, chlorine, nitro, phenyl, (1-4C)alkyl, trufluoromethyl, (1-4C)alkoxi or (1-4C)alkylamino; or (2-6C)hetercycloalkyl; R⁵is (di (1-4C)alkylamino, (1-4C)alkoxi, amio, hydroxy, (6C)arylamino, (di)(3-4C)alkenylamino, (2-5C)heteroaryl(1-4C)alkylamino, (6C)aryl(1-4C)alkylamino, (di)[(1-4C)alkoxi(2-4C)alkyl]amino, (di)[(1-4C)alkylamino2-4C)alkyl]amino, (di)[amino(2-4C)alkyl]amino or (di)[hydroxy(2-4C)alkyl]amino. The invention also relates to the pharmaceutical composition based on the compound with formula (I) and to the application of the compound with the formula (I).

EFFECT: novel tetrahydroquinolin derivatives with follicle-stimulating hormone receptors modulating activity are obtained.

10 cl, 44 ex

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RU 2 328 487 C2

Authors

Timmers Kornelis Marius

Karstens Villem Frederik Jokhan

Dates

2008-07-10—Published

2003-12-16—Filed